It found that there was no quality of life advantage in the group of women who received local therapy to the breast tumour. The drug works by recognizing and attaching to Trop-2 on cancer cells and then releasing a toxic drug that kills the cell. Read more of BCRF's SABCS 2020 coverage here. 2020 Sep;31(9):1223-1230. doi: 10.1016/j.annonc.2020.05.012. "When combined with the results of an earlier trial in Mumbai, India (Badwe et al, Lancet Oncol 2015), these results tip the scales against the possibility that local therapy to the breast tumour will help women live longer," said Dr. Khan. "Instead, we find that the adverse effects of surgery and radiation appear to balance out the gains in quality of life that were achieved with better control of the primary tumour.". In discussing the results, Dr. Rugo stressed that patients who had a longer disease-free interval before a metastatic diagnosis, as well as those who had not previously been treated with chemotherapy, tended to respond better overall. Amornrat Phuchom/iStock. Mammogram. Here, we conducted the FUTURE trial (ClinicalT … "Trials like TAILORx, and now E2108, help ECOG-ACRIN, in a partnership with the National Cancer Institute and investigators all over the world, fulfil our mission to identify the best treatments for an individual patient and maximise quality of life. Remember My Login. Cleveland Clinic researchers are getting ready to embark on a clinical trial testing a breast cancer vaccine. We are very pleased to announce that the San Antonio Breast Cancer Symposium will take place in 2020. "When making these decisions, it is important to focus energy and resources on proven therapies that can prolong life.". The San Antonio Breast Cancer Symposium 2020 (SABCS 2020) is one of the most important breast cancer conferences in the world and brings together the world’s leading breast cancer researchers, including those from Breast Cancer Trials. This year’s virtual meeting included a number of clinical trial presentations focused on these cancers. The ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) designed and led this trial, which was conducted in the NCI National Clinical Trials Network (NCTN) with funding from the National Cancer Institute, part of the National Institutes of Health. June 30, 2020. Several studies suggested that removal of the tumour in the breast with surgery would be beneficial. Password. The American Society of Clinical Oncology (ASCO) will highlight the data during the plenary session of its annual meeting to occur virtually from May 29-31 (Abstract LBA2). FDA Approves Phesgo as Injection Treatment for HER2-positive Breast Cancers. Clinical trials are research studies that involve people. At SABCS, BCRF investigator Dr. Hope Rugo presented results from a subgroup analysis looking at the benefit of pembro in each chemotherapy group (nab-paclitaxel, paclitaxel, and gemcitabine/carboplatin). "Based on the results of our study, women who present with a new diagnosis of breast cancer already in stage IV should not be offered surgery and radiation for the primary breast tumour with the expectation of a survival benefit," said lead investigator Seema A Khan, MD (Northwestern University). 1-4 The UK START-B and Ontario trials established 15- and 16-fraction schedules as new standards of care delivered over 21-22 days. Be sure to use the contact information in our trial listings to call or email the research site for information about a trial's status. The main goal of the E2108 trial was to see if the use of local therapy to the breast tumour would improve survival. Research News. TNBC is named for what it lacks: the three major receptors (estrogen, progesterone, and HER2) found in other breast cancers. Tags: ASCO. 14/12/2020. Dr. Mittendorf reported that patients receiving checkpoint inhibitor therapy did not experience additional burden on quality of life and functionality compared to those receiving chemotherapy alone. Clinical trials can be an important part of your treatment plan. IMpassion031 involved 333 newly diagnosed patients with TNBC who were randomly assigned to receive either atezolizumab plus chemotherapy (nab-paclitaxel, doxorubicin, or cyclophosphamide) or the same chemotherapy agents plus a placebo prior to undergoing breast cancer surgery. Anastrozole and Tamoxifen Both Prevent Breast Cancer for Postmenopausal Women 09/12/2020 Long-term follow-up of the IBIS-II DCIS clinical trial has found that Anastrozole and Tamoxifen are both effective in preventing breast cancer and DCIS, providing more treatment options for postmenopausal women with an early form of breast cancer. Starting about 20 years ago, this approach was questioned based on the idea that the primary tumour could be a source of re-seeding of cancer outside the breast. Testing checkpoint inhibitors with chemotherapy for TNBC. While the study was not designed to make statistical comparisons between the chemotherapy groups, an added benefit of immunotherapy was seen across all chemotherapy regimens, providing additional support for the use of anti-PD-L1 immunotherapy for the treatment of mTNBC. It accounts for 10 to 15 percent of breast cancers, including many driven by BRCA1/2 gene mutations, and it unfortunately lacks many targeted treatments. SABCS has a new New site www.sabcsmeetingnews.org. IMpassion031 is a phase III trial in patients with early-stage TNBC testing the safety and effectiveness of the checkpoint inhibitor atezolizumab used in tandem with standard chemotherapy prior to surgery (called neoadjuvant therapy). The trial is designed to compare the efficacy (as measured by progression-free survival) of the targeted agent sacituzumab govitecan (SG) versus chemotherapy. May 7, 2020. At this year’s virtual San Antonio Breast Cancer Symposium (SABCS)—the world’s largest scientific conference dedicated to breast cancer—investigators reported a number of key findings from trials testing immunotherapies and targeted agents for triple-negative breast cancer (TNBC), an aggressive form of the disease. Here, we highlight developments from notable TNBC trials. BeyondSpring Announces New Positive PROTECTIVE-2 Phase 3 Registrational Trial Results at the 2020 San Antonio Breast Cancer Symposium Published: Dec. 10, 2020 at 8:25 a.m. ASCENT is an open-label randomized phase III study in patients with mTNBC that has progressed on at least two chemotherapies. If an abnormality is detected on a screening mammogram, your doctor may recommend a diagnostic mam… Traditionally, it was thought that because metastases had occurred, local therapy would not provide any additional survival benefit beyond what systemic treatment could offer. In addition to the excitement around checkpoint inhibitors, new targeted agents for treating TNBC were also a focus at SABCS. Based on these findings, pembrolizumab was granted accelerated FDA approval in combination with chemotherapy in PD-L1-positive mTNBC patients with no prior treatment. About one in every 20 women diagnosed with breast cancer in the United States each year present with cancer that has already spread beyond the breast to other organs (also called stage IV, advanced, metastatic, or distant breast cancer). Each traditional phase I trial enrolled a mean of 1.6 patients with MBC per trial … We found 13 randomised studies testing adjuvant breast hypofractionated radiotherapy regimens against standard fractionation ranging in … Epub 2020 May 25. It became clear that a clinical trial was needed to provide women and their doctors with good information. If you prefer sending a donation by check, you can mail it to: From paying tribute to a loved one to workplace giving, there are a variety of ways to support research. Patients with stage IV breast cancer usually receive systemic treatment--drugs that travel through the bloodstream and treat disease throughout the body. New Clinical Trials for Stage IV Breast Cancer (September 2020) Ten new clinical trials for TNBC, HER2 positive, and other subtypes of metastatic (stage IV) breast cancer have been added to BreastCancerTrials.org (BCT) in the last month. We searched for primary research and reviews published in English between Jan 1, 1980, and April 22, 2020. At this year’s virtual San Antonio Breast Cancer Symposium (SABCS)—the world’s largest scientific conference dedicated to breast cancer—investigators reported a number of key findings from trials testing immunotherapies and targeted agents for triple-negative breast cancer (TNBC), an aggressive form of the disease. Dr. Sofia Merajver’s research has improved patients’ lives, including her own. PARP inhibitors work by blocking a protein that is used to repair damage to DNA that occurs during cell division. Confirming findings from the phase II study, patients receiving SG had better progression-free survival FS) and overall survival. Use the contact information in our trial listings to call or email the research site for information about a trial's status. ASCO 2020 was held in … Looking at emerging targeted agents for TNBC. Earlier reported results showed a clinically meaningful improvement in progression-free survival (9.7 months vs. 5.6 months) with the addition of pembro compared to placebo in patients whose tumors had high levels of the PD-L1 protein. The subgroup analysis presented by Dr. Sara Hurvitz of The University of California, Los Angeles included 468 patients (265 receiving SG and 233 receiving chemotherapy) and compared the efficacy of SG to chemotherapy based on the tumor expression of Trop-2 and germline (inherited) BRCA1/BRCA2 mutation status of the patient. At the 2020 ESMO meeting, researchers reported a 16 percent increase in pathological complete response (no invasive cancer at time of surgery) in patients receiving the checkpoint inhibitor therapy plus chemotherapy compared to those who received the placebo. 2. 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